Jean-Pierre Pelletier Selected Research

licofelone

8/2011	Risk factors predictive of joint replacement in a 2-year multicentre clinical trial in knee osteoarthritis using MRI: results from over 6 years of observation.
12/2010	Relationship between bone marrow lesions, cartilage loss and pain in knee osteoarthritis: results from a randomised controlled clinical trial using MRI.
6/2006	Licofelone reduces progression of structural changes in a canine model of osteoarthritis under curative conditions: effect on protease expression and activity.
1/2005	The protective effect of licofelone on experimental osteoarthritis is correlated with the downregulation of gene expression and protein synthesis of several major cartilage catabolic factors: MMP-13, cathepsin K and aggrecanases.
3/2004	The inhibition of subchondral bone resorption in the early phase of experimental dog osteoarthritis by licofelone is associated with a reduction in the synthesis of MMP-13 and cathepsin K.
7/2002	Study of the role of leukotriene B()4 in abnormal function of human subchondral osteoarthritis osteoblasts: effects of cyclooxygenase and/or 5-lipoxygenase inhibition.
7/2002	Licofelone (ML-3000), a dual inhibitor of 5-lipoxygenase and cyclooxygenase, reduces the level of cartilage chondrocyte death in vivo in experimental dog osteoarthritis: inhibition of pro-apoptotic factors.

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Jean-Pierre Pelletier Research Topics

Disease

95	Osteoarthritis 01/2022 - 01/2002
37	Knee Osteoarthritis 01/2022 - 02/2003
28	Pain (Aches) 01/2022 - 02/2003
12	Inflammation (Inflammations) 04/2022 - 12/2003
7	Arthritis (Polyarthritis) 01/2013 - 01/2002
6	Disease Progression 01/2019 - 11/2006
4	Rheumatoid Arthritis 06/2020 - 12/2002
4	Synovitis 01/2019 - 01/2010
3	Obesity 04/2022 - 01/2019
3	Fibrosis (Cirrhosis) 12/2017 - 04/2013
3	Osteoporosis 02/2016 - 06/2013
3	Sclerosis 11/2012 - 01/2006
3	Bone Resorption 09/2011 - 03/2004
2	Hypertrophy 04/2022 - 05/2012
2	Body Weight (Weight, Body) 01/2022 - 05/2012
2	Hyperalgesia 01/2019 - 01/2016
2	Hypersensitivity (Allergy) 01/2017 - 11/2016
2	Osteophyte 06/2006 - 06/2003
1	Insulin Resistance 04/2022

Drug/Important Bio-Agent (IBA)

11	Pharmaceutical PreparationsIBA 01/2019 - 02/2002
10	Chondroitin Sulfates (Chondroitin Sulfate)IBA 01/2017 - 05/2006
9	Analgesics (Analgesic Drugs)IBA 01/2022 - 05/2008
9	Glucosamine (Dona)IBA 10/2016 - 05/2006
8	Biomarkers (Surrogate Marker)IBA 01/2022 - 07/2002
7	PPAR gammaIBA 04/2013 - 01/2002
7	licofeloneIBA 08/2011 - 07/2002
7	Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)IBA 01/2005 - 03/2002
6	Metalloproteases (Metalloproteinases)IBA 12/2017 - 10/2003
5	Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA 02/2016 - 05/2008
5	Dinoprostone (PGE2)FDA Link 05/2014 - 12/2003
5	Peptide Hydrolases (Proteases)FDA Link 03/2014 - 06/2006
5	Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)IBA 04/2013 - 07/2002
5	CytokinesIBA 01/2011 - 01/2002
4	diacereinIBA 12/2020 - 04/2010
4	Celecoxib (Celebrex)FDA Link 12/2020 - 12/2010
4	Complement Factor D (Factor D)IBA 01/2020 - 04/2016
4	Iodoacetic AcidIBA 04/2019 - 01/2016
4	NeuropeptidesIBA 04/2019 - 01/2016
4	Interleukin-1 (Interleukin 1)IBA 01/2019 - 12/2002
4	Ephrin-B2 (Ephrin B2)IBA 12/2017 - 12/2008
4	strontium ranelate (protelos)IBA 03/2015 - 09/2011
4	Matrix Metalloproteinases (MMPs)IBA 04/2013 - 10/2003
4	Cyclooxygenase 2 (Cyclooxygenase-2)IBA 04/2013 - 02/2002
4	ChondroitinIBA 06/2011 - 01/2007
4	LigandsIBA 02/2011 - 01/2002
4	Arachidonate 5-Lipoxygenase (5 Lipoxygenase)IBA 06/2006 - 07/2002
3	Proteins (Proteins, Gene)FDA Link 01/2022 - 01/2005
3	Prostaglandin D2IBA 12/2020 - 01/2017
3	LipocalinsIBA 12/2020 - 06/2013
3	prostaglandin R2 D-isomerase (prostaglandin D2 synthase)IBA 12/2020 - 06/2013
3	AdipokinesIBA 01/2020 - 04/2016
3	Tramadol (K315)FDA LinkGeneric 01/2018 - 11/2016
3	LeptinIBA 01/2017 - 04/2005
3	ProstaglandinsIBA 01/2017 - 07/2002
3	Acetaminophen (Paracetamol)FDA LinkGeneric 02/2016 - 05/2008
3	Peroxisome Proliferator-Activated Receptors (PPAR)IBA 06/2013 - 02/2002
3	Matrix Metalloproteinase 13IBA 04/2013 - 02/2005
3	Cathepsin KIBA 02/2013 - 03/2004
3	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2013 - 01/2002
3	Prostaglandins EIBA 09/2011 - 07/2002
3	Diphosphonates (Bisphosphonates)IBA 06/2011 - 11/2006
3	Interleukin-1beta (Interleukin 1 beta)IBA 01/2010 - 03/2002
3	Nitric Oxide (Nitrogen Monoxide)FDA Link 01/2005 - 10/2002
2	SteroidsIBA 01/2022 - 02/2003
2	Lysophosphatidylcholines (Lysophosphatidylcholine)IBA 11/2019 - 01/2019
2	Phosphatidylcholines (Phosphatidylcholine)IBA 11/2019 - 01/2019
2	Pregabalin (Lyrica)FDA Link 01/2019 - 02/2005
2	Meloxicam (Mobic)FDA LinkGeneric 01/2018 - 11/2016
2	Gabapentin (Neurontin)FDA LinkGeneric 01/2018 - 02/2005
2	Hyaluronic Acid (Hyaluronan)IBA 01/2018 - 09/2017
2	DisintegrinsIBA 12/2017 - 04/2013
2	EphB4 ReceptorIBA 11/2012 - 12/2008
2	Naproxen (Naprosyn)FDA LinkGeneric 08/2011 - 12/2010
2	tiludronic acid (tiludronate)FDA Link 06/2011 - 01/2011
2	Interleukin-17 (Interleukin 17)IBA 12/2008 - 12/2002
2	PPAR-gamma AgonistsIBA 07/2007 - 02/2005
2	Pioglitazone (Actos)FDA Link 07/2007 - 02/2005
2	Therapeutic UsesIBA 02/2005 - 03/2004
2	Lipoxygenase (Lipoxygenase-1)IBA 03/2004 - 03/2002
2	EnzymesIBA 01/2004 - 10/2002
2	Leukotriene B4IBA 07/2002 - 03/2002
1	Phospholipids (Phosphatides)FDA LinkGeneric 04/2022
1	Glucose (Dextrose)FDA LinkGeneric 04/2022
1	Insulin (Novolin)FDA Link 04/2022
1	Phenylalanine (L-Phenylalanine)FDA Link 04/2022
1	Tryptophan (L-Tryptophan)FDA Link 04/2022
1	Branched-Chain Amino AcidsIBA 04/2022
1	Amino Acids FDA Link 04/2022
1	Narcotics (Narcotic Analgesics)IBA 01/2022
1	turmeric extractIBA 11/2020
1	Tumor Necrosis Factor InhibitorsIBA 06/2020
1	Zoledronic Acid (Zometa)FDA Link 01/2020
1	Adrenal Cortex Hormones (Corticosteroids)IBA 01/2020

Therapy/Procedure

12	Therapeutics 01/2022 - 01/2004
10	Knee Replacement Arthroplasty (Total Knee Replacement) 01/2022 - 08/2011
5	Replacement Arthroplasty 02/2016 - 01/2010
4	Injections 01/2022 - 02/2003
3	Analgesia 01/2019 - 01/2016
2	Aftercare (After-Treatment) 01/2018 - 05/2008
1	Diet Therapy (Therapy, Diet) 04/2022